Ki-67 staining of the lung from CC-LR/TLR4KO and CC-LR/TLR9KO mutant mouse models showed a reduction in tumor cell proliferation by ~15%, while CC-LR/TLR2KO had a greater reduction of 50% in Ki-67 positive cells (Figures 2A, B). This evidence concerns the gene MKI67 and neoplasm.