To do this, we developed CC-LR mice with airway specific deletion of MyD88 (LR/MyD88Δ/Δ), and IKKβ (LR/IKKβΔ/Δ) separately, then exposed them to COPD-inducing conditions like TLR KO models. The gene discussed is MYD88; the disease is chronic obstructive pulmonary disease.