Here, GO terms related to hormone secretion and transport, such as, are up-regulated in SCT (Figure 2A), and GO term “positive regulation of ERK1 and ERK2 cascade” that is related to the development of SCT is also up-regulated, probably reflecting a compensatory effect in response to the development deficiency in the placenta. This evidence concerns the gene MAPK1 and spondylocarpotarsal synostosis syndrome.