JAK2 and Cognitive impairment: revealed that HF-rTMS could regulate the Janus kinase 2 (JAK2)-signal transducer and transcription 3 (STAT3) pathways, and further inhibit microglial activation as well as promote the switch of microglia toward the neuroprotective M2 phenotype, resulting in alleviation of ischemic white matter damage and improvement of cognitive impairment (147).