revealed that HF-rTMS could activate BDNF/tropomyosin-related kinase B (TrkB) signaling pathway and antiapoptotic pathways to increase number of BrdU+ NESTIN+ cells, decrease Bcl-2 expression and elevate Bax expression, leading to the improvement of the cognitive impairment of rats with ischemic stroke (123). The gene discussed is NTRK2; the disease is Cognitive impairment.