RUNX2 and osteoporosis: Upregulation of miR‐19a‐3p is reported to reduce age‐induced bone loss in mice and increase osteogenesis in mouse BMSCs.(35) Moreover, overexpression of miR‐19a‐3p is known to alleviate the progression of osteoporosis by upregulating RUNX2 and OCN gene expression and enhancing alkaline phosphatase activity in human BMSCs.(36) Nevola et al.(58) noted that miR‐19a‐3p expression was higher in individuals without incident fracture compared to those with a fracture and was positively associated with increased bone mineral density and beta‐blocker usage.