FGF23 and osteomalacia: Mutations in the Phosphate Endopeptidase Homolog, X‐linked (PHEX) gene (located at Xp22.1) that encodes a transmembrane endopeptidase, primarily expressed in osteoblasts, osteocytes, and teeth, cause elevated fibroblast growth factor 23 (FGF23) and consequent renal phosphate wasting and defects in the hydroxylation of vitamin D. The altered mineral metabolism then leads to diverse skeletal abnormalities, including rickets, osteomalacia, and dental health issues.(1, 2, 3, 4, 5, 6, 7)