Interestingly, LRP5‐related EOOP has recently been classified in the same group as osteogenesis imperfecta in the classification of genetic skeletal disorders.(22, 51) Our results strengthen the idea of a continuum between LRP5 EOOP and osteogenesis imperfecta, as LRP5 variants can be responsible for alterations of the collagen structure of bone extracellular matrix. The gene discussed is LRP5; the disease is osteogenesis imperfecta.