LRP5 is also essential for the development of the retinal vasculature through a variant of Norrin/β‐catenin pathway.(24, 25) Mutations of LRP5 are responsible for loss of vision in the OPPG syndrome and other familial exudative vitreoretinopathy (FEVR).(26, 27) Previous studies reported ocular features in young adults with heterozygous LRP5 variants.(28, 29) However, whether osteoporotic patients have vitreoretinopathy or any vessel abnormalities remains unclear. This evidence concerns the gene LRP5 and Vitreoretinopathy.