NFIX and Marinesco-Sjogren syndrome: Heterozygous mutations in the NFIX gene can lead to two rare allelic disorders, Malan syndrome (MAL; MIM #614753) and Marshall‐Smith syndrome (MSS; MIM #602535).(1, 9) MAL is an overgrowth disorder, characterized by a slender habitus, long hands and advanced bone age, moderate to severe intellectual disability, unusual facial phenotype consisting of a long, triangular face with a prominent forehead, everted lower lip and prominent chin, and behavioral problems, which are usually dominated by anxieties and, less frequently, by aggression(9, 10, 11, 12) (Table S1).