Consistent with the existing cardiovascular disease literature (10, 14–16), we found that STEMI patients with higher serum YKL-40 levels tended to be older, male, diabetic, family history of coronary heart disease, anterior myocardial infarction, had a higher proportion of multivessel disease, and greater Gensini score. This evidence concerns the gene CHI3L1 and coronary artery disorder.