Gene–disease association information were as follows (Figure 4A): HIF1A is associated with heart failure and cardiac hypertrophy; IL6 is associated with heart failure and cardiomyopathy; PTGS2 is associated with aortic aneurysms, heart failure, cardiac arrhythmias, cardiomyopathy, and CVD. The gene discussed is PTGS2; the disease is cardiac rhythm disease.