Gene–disease association information were as follows (Figure 4A): HIF1A is associated with heart failure and cardiac hypertrophy; IL6 is associated with heart failure and cardiomyopathy; PTGS2 is associated with aortic aneurysms, heart failure, cardiac arrhythmias, cardiomyopathy, and CVD. This evidence concerns the gene PTGS2 and cardiac arrhythmia.