Thereby, as shown in a recent work employing an experimental model of myocardial ischemia/reperfusion injury in P-selectin deficient bone marrow chimeric mice, platelet-leukocyte aggregates seem to be dispensable for myocardial ischemia/reperfusion injury as quantified by left ventricular ejection fraction (LVEF) upon 35 min of left anterior descending (LAD) coronary vessel obstruction and subsequent 24 h reperfusion (88). This evidence concerns the gene SELP and myocardial ischemia.