CYP2E1 and central nervous system cancer: Our previous study showed that the activity of CYP2E1 was increased in peritumoral tissues of hepatocellular carcinoma (HCC), and inhibition of CYP2E1 could significantly inhibit the occurrence and development of HCC.[31, 34] In the present study, we investigated the expression of CYP2E1 in peritumoral cells of glioma and studied its relationship with glioma occurrence and progression.