In conclusion, we discovered a previously unknown pro‐tumorous mechanism in which the CYP2E1‐PPAR‐γ‐STAT‐1/NF‐κB/STAT‐3/STAT‐6 axis induced GBM cell proliferation and inhibited apoptosis to fuel tumorigenesis and tumor growth. This evidence concerns the gene CYP2E1 and glioblastoma.