HMGA2 and hereditary clear cell renal cell carcinoma: HMGA2 is highly expressed in several types of cancer, such as colorectal and renal cell carcinomas, breast cancers, lung cancers, and pancreatic ductal adenocarcinomas,31 while a multitude of studies have shown that higher level of expression of HMGA2 is associated with a poorer prognosis and a progression of the disease.