In fact, post‐translational modifications of HMGA2 have profound effects on its biological functions, one example is HMGA2 acetylation, which enhances its ability to bind to DNA on target genes while maintaining its stability, it results in HMGA2 accumulation and the progression of esophageal squamous cell carcinoma.34 The gene discussed is HMGA2; the disease is esophageal squamous cell carcinoma.