IFI16 and infection: Infection of cells expressing ΔIDR-IFI16 with ICP0-RF HSV-1 resulted in three-fold higher virus titers than cells expressing WT-IFI16 and greater than two-fold higher than cells expressing FUS-IFI16, indicating a defect in the ability of ΔIDR-IFI16 to inhibit viral production (Figure 3F).