For example, aberrant expression of the nuclear DNA sensor IFI16 has been associated with several autoimmune diseases, including Sjögren's syndrome (56), systemic lupus erythematosus (57), systemic sclerosis (58,59), inflammatory bowel disease (60,61), rheumatoid arthritis (58), and psoriasis (62,63). The gene discussed is IFI16; the disease is systemic sclerosis.