For example, aberrant expression of the nuclear DNA sensor IFI16 has been associated with several autoimmune diseases, including Sjögren's syndrome (56), systemic lupus erythematosus (57), systemic sclerosis (58,59), inflammatory bowel disease (60,61), rheumatoid arthritis (58), and psoriasis (62,63). This evidence concerns the gene IFI16 and rheumatoid arthritis.