In humans, two proteins share significant similarities with yeast Trm9 and both interact with TRMT112: ALKBH8 modifies tRNAs in a similar manner to Trm9 (36,37) while the biochemical function of TRMT9B (also known as KIAA1456 or hTrm9L), a protein acting as a tumor suppressor, remains to be clarified (38,39). The gene discussed is ALKBH8; the disease is neoplasm.