Additional genes have been identified associated with ADTKD, such as uromodulin (UMOD), mucin-1 (MUC1), HNF1B and α1-subunit of translocon 61 (SEC61A1), with evidence supporting further genetic heterogeneity (Bleyer et al., 2017; Devuyst et al., 2019). The gene discussed is SEC61A1; the disease is autosomal dominant medullary cystic kidney disease with or without hyperuricemia.