also clarified that Fstl1 facilitates the immunosuppressive of MSCs on macrophages and guarantees the anti‐fibrotic effect of MSCs in liver fibrosis.[28] Fstl1 is highly expressed in activated HSCs, while Fstl1 knockdown effectively suppresses HSCs proliferation by the TGF‐β1/Smad3 signaling pathway.[29] In our study, Fstl1 was also highly expressed in cirrhosis and regulated by Kcnq1ot1 and miR‐374‐3p. Here, SMAD3 is linked to Hepatic fibrosis.