SPARC and cirrhosis of liver: This was in accordance with the RNA sequencing data that miR‐374‐3p is downregulated and Fstl1 is upregulated in mice with liver cirrhosis.[16] Fstl1 is a secreted glycoprotein that belongs to the follistatin and SPARC families.[25] Studies have shown that Fstl1 contributes to the progression of liver fibrosis.[26] Xu et al.