KLB and metabolic dysfunction-associated steatotic liver disease: We conclude that up‐regulation of DNA methyltransferases by nutrient‐rich diets may result in hypermethylation of the Klb promoter and subsequent down‐regulation of Klb expression, thereby impairing fatty acid oxidation; this may in turn contribute to the development of NAFLD through the suppression of oxidative phosphorylation and fatty acid oxidation in male C57BL/6J mice.