DNA demethylation can be made by a family of enzymes called the TETs including members TET1, TET2, and TET3 that are capable of removing the methyl group from 5‐methylcytosine.[6] To study the physiological significance of TETs in the development of HFD‐induced hepatic steatosis, we first determined whether HFD feeding alters Tets’ mRNA expression in the liver of mice. This evidence concerns the gene TET3 and fatty liver disease.