UBE3A and Hepatic steatosis: Recently the E3 ligase ubiquitin‐protein ligase E3A (UBE3A) has been reported to prevent HFD‐induced hepatic steatosis in mice.[20] Interestingly, ATAC‐seq analysis revealed reduced peak reads at the Ube3a promoter in the liver of HFD‐fed mice, which was associated with decreased Ube3a mRNA reads revealed by RNA‐seq data (Figure9A).