Recently the E3 ligase ubiquitin‐protein ligase E3A (UBE3A) has been reported to prevent HFD‐induced hepatic steatosis in mice.[20] Interestingly, ATAC‐seq analysis revealed reduced peak reads at the Ube3a promoter in the liver of HFD‐fed mice, which was associated with decreased Ube3a mRNA reads revealed by RNA‐seq data (Figure9A). Here, UBE3A is linked to fatty liver disease.