Further KEGG pathway analysis of the differentially expressed genes revealed 10 significantly up‐regulated pathways, among which oxidative phosphorylation was top‐ranked, and a dozen down‐regulated pathways, including the inflammatory pathway NF‐κB and the hepatic fibrosis signaling pathway (Figure 3E), two hallmarks of NASH development. The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatohepatitis.