Second, it is possible that acquired cerebral tauopathies with more regional specificity than that typically associated with post-mortem-verified CTE-NC may account for ante-mortem neurocognitive impairment or that FTP may not detect specific trauma-related tau isoforms.47 It is also possible that FTP shows only a strong affinity for p-Tau in those with severe disease.11 This evidence concerns the gene MAPT and nevus comedonicus syndrome.