MAPT and mood disorder: Disease processes including hypertension, mood disorders, chronic inflammation, and disordered sleep may be underappreciated causes of neurocognitive complaints.17,48,49 Future work examining the diagnostic accuracy of newer generation p-Tau PET tracers, the clinical correlates of entorhinal cortex p-Tau uptake, and the role of alternative causes of neurocognitive impairment represent a scientific imperative.48