MAPT and neurodegenerative disease: FreeSurfer-derived ROI analyses revealed a marginally significant relationship between duration of NFL career and FTP uptake within the entorhinal cortex after adjustment for age, race, and position, an area in which p-Tau deposition has been associated with cognitive aging and the emergence of neurodegenerative disease.39,40 Results across all analyses were similar when we limited the player cohort to older players and separately to players with subjective cognitive complaints.