In an experimental AAA model created by transient intra-aortic porcine pancreatic elastase infusion in normoglycemic mice, administration of metformin was found to suppress both AAA formation and progression, and was associated with aortic medial elastin and smooth muscle cells preservation, reduced immune cell infiltration, and reduced mural neovessel density [34]. The gene discussed is ELN; the disease is triple-A syndrome.