In hematopoietic malignancies, when gene expression profiles of normal, chronic, and sequentially transplanted acute crisis chronic myeloid leukemia (CML) progenitors were compared, it was found that IFN-γ pathway gene expression was increased, along with enhanced ADAR1 p150 expression and increased adenosine-inosine RNA editing during CML progression [52, 70, 123]. Here, IFNG is linked to chronic myelogenous leukemia, BCR-ABL1 positive.