Our preliminary analysis also showed that higher tissue sEV miR-142-3p levels were accompanied by fewer Treg cells in HT tissue (p = 0.004, Fig. 3A), and higher miR-142-3p in T lymphocytes indicated less Foxp3 expression (p = 0.005, Fig. 3B), which advises us to examine whether the highly expressed miR-142-3p in T lymphocytes can control Treg biological properties in HT. The gene discussed is FOXP3; the disease is hematocrit.