VEGFA and pancreatic adenocarcinoma: PCI-27483 is a small molecule that inhibits the TF: FVIIa-complex and signaling downstream of PAR2, including MAPKs and Akt phosphorylation, c-fos induction, vascular endothelial growth factor (VEGF), and IL8 secretion as an autocrine growth factor known to induces chemotaxis and invasion in BxPC3 cell line (pancreatic adenocarcinoma).