The subsequent experiments showed that shKNTC1 and SYT7 + shKNTC1 showed similar effects on CLL development, as well as inhibition of cell proliferation (Fig. 6D), promotion of cell apoptosis (Fig. 6E), arrest of cell cycle in G2 phase (Fig. 6F), and suppression of cell migration (Fig. 6G). This evidence concerns the gene SYT7 and B-cell chronic lymphocytic leukemia.