MDM2 and acute myeloid leukemia: Our western blotting results showed that knockdown of Circ_0001187 resulted in a dramatic increase in the expression of oncogenes (MDM2) and sharply decreased the expression of apoptosis-associated genes (p53 and P21) in AML cells, and the opposite trend was observed by Circ_0001187 overexpression in AML cells (Fig. 2F).