WHO recommends that antihypertensive drugs be started when systolic blood pressure is 130–139 mmHg in patients diagnosed with hypertension, concomitant cardiovascular disease, or high cardiovascular risk (such as diabetes mellitus or chronic kidney disease).In the initial treatment, any two of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin-receptor blockers (ARBs), diuretics (thiazide or thiazide-like) and long-acting dihydropyridine calcium channel blockers (CCBs) can be selected for combination therapy. The gene discussed is ACE; the disease is cardiovascular disorder.