The data also showed that AQP8 expression was significantly downregulated in colorectal adenocarcinoma, rectal adenocarcinoma, and UCEC (uterine endometrial carcinoma), but significantly upregulated in renal clear cell carcinoma, hepatocellular carcinoma, and thyroid carcinoma compared with normal tissues. The gene discussed is AQP8; the disease is rectum adenocarcinoma.