And cluster 2 enriched in complement and coagulation cascades, hematopoietic cell lineage, aldosterone-regulated sodium reabsorption, ECM receptor interaction, arrhythmogenic right ventricular cardiomyopathy (ARVC), dilated cardiomyopathy, hypertrophic cardiomyopathy (HCM), taurine and hypotaurine metabolism, renin-angiotensin system (Fig. 4A). The gene discussed is REN; the disease is hypertrophic cardiomyopathy.