In addition to reports that suggest the existence of an adenoma-SRCC sequence [24, 25], the molecular characteristics of SRCC have been reported to possibly arise from a separate genetic pathway, accompanied by a lower frequency of APC mutations; the presence of less common KRAS, BRAF, and PI3K mutations; frequent SMAD4 mutations; and ordinary MSI-H status [26]. This evidence concerns the gene BRAF and adenoma.