Application of compression before virus infection significantly suppressed IFN-β protein levels at 48, 72, and 96 hpi (P = 0.0313, P = 0.0469, P = 0.0469, respectively) and IFN-λ at 72 hpi (P = 0.0313; Fig. 2, A and B; individual virus-infected IFN protein data points at 48, 72, and 96 hpi are shown in Supplemental Fig. S3, A and B; https://doi.org/10.6084/m9.figshare.19217628). This evidence concerns the gene IFNB1 and viral infectious disease.