When we overexpressed VDAC1 in DYNLT1 knockdown breast cancer cells and detected the changes in cellular ATP levels, we found that the reduced ATP levels after DYNLT1 knockdown was significantly increased after overexpression of VDAC1 (Fig. 5I and Fig. S3F), and WB results showed VDAC1 protein levels after overexpression in DYNLT1 knockdown cells. Here, VDAC1 is linked to breast cancer.