The signaling pathways that promote tumor tumorigenesis and progression, such as JAK-STAT signaling pathway [48], NF-kappa B signaling pathway [49], PI3K-Akt signaling pathway [50], Ras signaling pathway [51], and MAPK signaling pathway [52], were activated in the high-risk group, which may explain why the high-risk group experienced a worse prognosis. This evidence concerns the gene AKT1 and neoplasm.