In those patients, the correlation between the serum and tumor tissue levels was marginal for S100A8 (r = 0.38, P = 0.060; Fig. 3c), while a significant positive correlation was noted between the serum and tumor tissue levels of S100A9 (r = 0.41, P = 0.042; Fig. 3d). The gene discussed is S100A8; the disease is neoplasm.