Backward multi-variate regression models showed that a higher dosage of alcohol consumption (adjusted coefficient: 4.52 [95% CI: 3.14–5.91], per 10 g+/day, p < 0.001), ALDH2 Vt (adjusted coef: 7.67 [95% CI: 2.15–13.18], p = 0.003), female gender, history of hypertension, coronary artery disease (CAD), and diabetes were independently associated with prolonged QTc (Fig. 1b). The gene discussed is ALDH2; the disease is hypertensive disorder.