In addition, based on exonic breakpoint, there were two types of BRAF fusions commonly found in PXA; type I BRAF retains exon 8–18 of BRAF, indicating conservation of CR2 domain with their autoinhibitory roles42, while type II BRAF involves exon 9–18 of BRAF, indicating loss of CR2 domain but retaining portion of some of the autoinhibitory moiety (Fig. 5F)43. Here, CR2 is linked to pleomorphic xanthoastrocytoma.