In the experimental autoimmune uveitis (EAU), an animal model mimicking human autoimmune uveitis14, Th17 cells were found to be a predominantly pathogenic mediator in the development of uveitis by producing a set of proinflammatory cytokines, including IL-17A, IL-17F, IL-22, and GM-CSF15,16. The gene discussed is IL17A; the disease is uveitis.