KCNA1 and Ataxia: Here, Native American ataxia remedy extracts had relatively minor effects on Kv1.1-V408A activity, with nettle and Pacific ninebark (roots or leaves) inducing hyperpolarizing shifts in EM, and Pacific ninebark leaves inducing a negative shift in the voltage dependence of activation, although this was not quantifiable due to the very small tail currents (Supplementary Fig. 7).