Similarly, we found that some extracts also activated Kv1.2 (Fig. 1) and further in vivo testing will be important to decide whether this is beneficial or problematic in various ataxia models; it is also important to note that KCNA2 gene variants are also implicated in forms of episodic ataxia associated with myoclonic epilepsy, spastic paraplegia, and also epileptic encephalopathy in the absence of ataxia78–80. This evidence concerns the gene KCNA2 and Spastic paraplegia.