CD8A and colorectal cancer: To learn more, we generated a library of 371 CD8 T cell clones recognizing 19 neoantigens, TAAs and virus epitopes (Supplementary Table 1) from 16 patients with melanoma, ovarian, lung or colorectal cancer and 6 healthy donors (Supplementary Table 2), and investigated the functional and structural profiles of their TCRs in 190 and 338 clones, respectively (Fig. 1a).