DDOST and Hepatic fibrosis: In the present work, we performed a range of in vitro and in vivo experiments to investigate the important role of ferroptosis, a novel form of regulated cell death triggered by iron-dependent lipid peroxidation, in the pathogenesis of liver fibrosis in NASH with T2DM, and we further addressed whether AGER1 could improve liver fibrosis in NASH with T2DM by inhibiting ferroptosis.