The C-terminal residues of NF2 and a fully folded FERM domain are thought prerequisite for the formation of the head-to-tail interaction (Grönholm et al, 1999; Gutmann et al, 1999), membrane localization (Brault et al, 2001), and tumor suppressor function (Sherman et al, 1997). This evidence concerns the gene NF2 and neoplasm.