In addition to functional differences associated with NF2 versions lacking exons 2–3 (Giovannini et al, 1999; Luo et al, 2015), several patient-derived NF2 related-schwannomatosis NF2 missense mutations within the N-terminal FERM domain were found which impaired NF2 interactions with DCAF1 (Li et al, 2010). The gene discussed is DCAF1; the disease is schwannomatosis.