We tested tumor suppressive NF2 isoform 1 and the shorter non-tumor suppressive isoform 7 (Fig 1A) for protein interactions and found three isoform-specific NF2 PPIs in a phospho-Y2H screen, that involves an active protein kinase to additionally detect protein interactions that are modulated by phosphorylation (Grossmann et al, 2015; Jehle et al, 2022). The gene discussed is WEE1; the disease is neoplasm.