Its extracellular portion has about 40% of sequence homology to myelin P0, while its intracellular segment has two immunoreceptor tyrosine-based inhibition motifs (ITIMs) that specifically interact with SHP-2, a tyrosine phosphatase involved in a multitude of cellular processes including cancer development, metabolism, and responses to oxidative stress [4–8]. The gene discussed is PTPN11; the disease is cancer.