KC samples showed a mean ALU editing index of 1.08 ± 0.08, compared to 1.78 ± 0.24 for the CT group in EXP1 (Fig. 1A, P = 0.00013, Mann-Whitney U test), a reduction confirmed also in EXP2, with 0.71 ± 0.04 in the KC group compared to 0.88 ± 0.1 in the CT group (P = 6.2e−13, Mann-Whitney U test; Fig. 1B). The gene discussed is XPO1; the disease is keratoconus.