Several of the keratins displaying higher number of editing sites in the KC group have been reported as involved in different human diseases, such as KRT4 in White sponge nevus, KRT5 in epidermolytic hyperkeratosis, KRT6C in focal or diffuse nonepidermolytic palmoplantar keratoderma and KRT76 in plantar wart.61 Here, KRT76 is linked to epidermolytic ichthyosis.