The top 10 significant genes that demonstrated differential CGI hypermethylation and corresponding decrease mRNA in PCa compared to normal tissues are CDH3, HDAC5, ARPC2, MBNL2, WASF2, RASGRP2, CDKN1C, MRVI1, PGCP, and YAP1. The gene discussed is RASGRP2; the disease is posterior cortical atrophy.