These studies were limited and focused on a few genes, notably tumour suppressors (GSTP1, RARβ2, RASSF1A, CD44, CAV1, CDH13, CDH1, and TIMP3), whereby differential DNA methylated mediated gene silencing of tumour suppressor genes and could contribute to aggressive disease milieu observed in AA men. Here, RASSF1 is linked to neoplasm.