Similarly, top candidate genes with differential CGI hypomethylation and corresponding increased mRNA expression in PCa compared to benign tissues are XPOT, MARS, METTL1, XPO5, EIF2A, MTHFD2, MTHFD1L, MTHFD2L, EIF5A, and SEC61A1. This evidence concerns the gene EIF2A and posterior cortical atrophy.