Similarly, top candidate genes with differential CGI hypomethylation and corresponding increased mRNA expression in PCa compared to benign tissues are XPOT, MARS, METTL1, XPO5, EIF2A, MTHFD2, MTHFD1L, MTHFD2L, EIF5A, and SEC61A1. The gene discussed is MTHFD2; the disease is posterior cortical atrophy.