TBX21 and neoplasm: To assess the impact of T-box TF deficiency on NK cells’ ability to control tumor in vivo, we engrafted TRAC gRNA/CRISPR–edited (control NK), TBX21-edited, EOMES-edited, or T+E edited NK cells into NOD-scid IL2Rgnull (NSG) mice, which lack T, B, or NK cells and thus allow for xenograft of human cells (Figure 1E) (26).