Previous studies indicate that in LCWE-induced KD vasculitis, monocytes and macrophages are the main sources of IL-1B (46, 47), while neutrophils and eosinophils also express transcripts (Il1b, Nlrp3, Casp1, and Pycard) and have the capacity to produce IL-1B (7). Here, CASP1 is linked to vasculitis.