After observing that sleep rebound behaviors in AD-tau–injected APPPS1:E4 mice were significantly affected, especially in male APPPS1:E4 mice, we next assessed whether Aβ-induced NP-tau pathology in APPPS1:E4 male mice exacerbates their sleep quality and quantity under non-SD conditions compared with noninjected APPPS1:E4 male mice. Here, MAPT is linked to Alzheimer disease.