To provide further insight into the SERPINB3-mediated suppressive immune response, we used a human phosphorylation pathway profiling array that contained 5 cancer-associated pathways — MAPK, AKT, JAK/STAT, NF-κB, and TGF-β — and identified 14 proteins with upregulated phosphorylation (fold change ≥2) and 4 proteins with downregulated phosphorylation (fold change ≤ 0.5) in Caski/B3 versus Caski/Ctrl cells (Supplemental Figure 9). Here, AKT1 is linked to cancer.