Previous studies have demonstrated that the global P2ry2-KO model develops salt-resistant hypertension (37), impaired ATP-evoked relaxation in aorta (38), and greater infarct size and impaired heart function in a myocardial infarction model, as in vivo treatment using MRS2768 not only protects the heart from ischemic damage (39, 40) but also prevents vascular calcification (41, 42). The gene discussed is P2RY2; the disease is myocardial infarction.