P2RY2 and hypertensive disorder: To determine the necessity of P2Y2 receptors specifically in principal cells for P2Y2-sensitive decreases in blood pressure, we compared changes in mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) in a DOCA-salt model of hypertension in control littermates and PC-P2ry2–KO mice in response to treatment with the selective P2Y2 receptor agonist, MRS2768.