Recently, a high-throughput screening identified DHCA as being one of the two phytochemicals effective in promoting resilience against stress via reducing IL-6 production by inhibiting DNA methylation, which modulated the brain synaptic plasticity and peripheral inflammation, making it a strong candidate for treating stress disorders and depression, either alone or in combination with currently available antidepressants [54]. This evidence concerns the gene IL6 and major depressive disorder.