Possible mechanisms discussed include platelet aggregation, depletion of serotonin content of platelets, inhibition of blood clotting [65], mast cell degranulation, decrease in histamine release from mast cells [66], decrease of mRNA levels of protease-1 in mast cells [67], reduction in cytokine storms in COVID-19 patients because of atypical response of mast cells to SARS-CoV-2 [65], lysosomotropism [68], lysosomal trafficking to escape from infected cells [69], or functional inhibition of acid sphingomyelinase [70]. The gene discussed is SMPD1; the disease is COVID-19.