For example, using samples from convalescent COVID-19 patients, Ladner et al. demonstrated that SARS-CoV-2 elicited antibodies that cross-recognized pandemic and endemic HCoV antigens at two Spike S2 subunit epitopes, and they postulated that previous HCoV exposures could influence the immune response to epitopes of SARS-CoV-2 (19). Here, CHMP5 is linked to COVID-19.